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KMID : 0624620140470040192
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BMB Reports
2014 Volume.47 No. 4 p.192 ~ p.196
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The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1
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Harikrishna Reddy R
Kim Hack-Young
Noh Kwang-Mo
Kim Young-Jun
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Abstract
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RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.
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KEYWORD
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Cardiac hypertrophy, Cell cycle regulation, Neuronal gene silencing, SCP1, Small CTD phosphatases
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